The verb resign comes from the noun resignation. When you resign from a job, you give up the job. You tender your resignation. To resign is to quit or walk away from a job.
I must resign from my teaching position.
The president of the company plans to resign from his post next month.
The verb re-sign means to sign again.
I signed the paperwork once, but it was lost, so I must re-sign it.
Let me re-sign that contract for you.
Use resign when quitting a job. Use re-sign when you sign something a second time.
It’s your turn. Decide if you should use resign or re-sign in this sentence. I need your signature again, so please ____ this form. Did you use re-sign? Good for you!